SeroPlus was developed by Pure Encapsulations in conjunction with Dr. James Greenblatt as part of The Integrative Mental Health Series, a line of products based on scientific findings and decades of clinical experience. SeroPlus contains 5-HTP to support healthy mood balance by providing serotonin building blocks. By helping to form serotonin, 5-HTP balance serotonin function in the brain for emotional wellness. Also critical to each formulation in this series is the inclusion of vitamin B₆, zinc and Metafolin^® L-5-MTHF cofactors; L-5MTHF is the form of folate that easily crosses the blood-brain barrier. These nutrients are often depleted in individuals due to medications, inadequate diets and toxic environmental exposures, compromising the ability to properly metabolize nutrients. Along with zinc, vitamin B₆ is a cofactor in amino acid metabolism, including the metabolism of 5-HTP into serotonin.